Product NameCXCR2 Rabbit pAbGene ID3579SwissProt IDP25025Gene NameCXCR2Alternative NamesCXCR2; IL8RB; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD antigen CD182BackgroundThe protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in inTinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.Research FieldImmunologyProduct CategoriesPrimary antibodyHostRabbitReactivityHumanApplicationWB,IHC-P,ELISADilution RatioWB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000Molecular WeightCalculated MW: 41 kDa; Observed MW: 41 kDaClonalityPolyclonal AntibodyClonality No.-IsotypeIgGImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human CXCR2.PurificationAffinity PurifiedConjugationUnconjugatedModificationUnmodifiedFormLiquidBuffer SystemLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

50ul/100ul